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Plenary Talks


Plenary Talk 1 : Structures and mechanisms of the pro-survival Bcl-2 family proteins, Inhibitors of programmed cell death: Genetics, systems and structural biology approaches to human diseases :
Ho Sup Yoon (Division of Structural Biology & Biochemistry School of Biological Sciences,Nanyang Technological University,60 Nanyang Drive Singapore 637551)
Biography    
Ho Sup Yoon is currently Professor in the School of Biological Sciences, Nanyang Technological University, Singapore. He received BSc degree from Seoul National University, MSc degree from Korea Advanced Institute of Science and Technology (KAIST), and PhD degree from University of Chicago. He then joined Abbott Laboratories in 1993 and contributed to various drug discovery projects and in particular played a pioneering role in deciphering biological function of Pleckstrin homology (PH) domain, identification of phosphatidylinositol 4,5-bisphosphate (PIP2) as PH domain’s ligand, molecular mechanism of the pro-survival Bcl-2 family proteins and developing their inhibitors as anti-cancer drugs, which are currently in clinical trials. Prof Yoon left Abbott early 2002 and joined School of Biological Sciences, Nanyang Technological University as a founding faculty member and appointed as Head, Division of Chemical Biology & BioTechnology from 2010 to 2011 and Head, Division of Structural Biology & Biochemistry from 2011 to 2014.
Prof. Yoon’s current research programs focus on regulatory mechanism of Bcl-2 family proteins and roles of immunophilins in human diseases including cancer, malaria, and neurodegenerative diseases. He has published on the order of 100 papers in highly regarded journals with more than 6000 citations and holds 6 patents. Prof Yoon was the recipient of Abbott Drug Discovery Impact Award 2000. He is currently an Editorial Board member of the Journal, Genomics, Proteomics & Bioinformatics.
Abstract    

Life and death processes are tightly modulated through complex networks of regulatory molecules in cells. Considering the Bcl-2 family serving as a key homeostatic modulator between life and death programmed cell death pathways and their errant behaviors are frequently connected to chemoresistance in cancer therapy, targeting the pro-survival Bcl-2 family members is certainly a promising anticancer therapeutic strategy. Over the years, extensive biochemical and structural studies have provided insights into their canonical molecular mechanisms of action and assisted designing inhibitory molecules targeting protein-protein interaction between the pro-and anti-apoptotic Bcl-2 family proteins. On the other hand, alternative regulatory mechanisms of Bcl-2 family have been also accumulating in recent years. The immunosuppressive drug FK506-binding protein (FKBP) family proteins interact with Bcl-2 and aids Bcl-2’s guardian role in cell survival pathways. The tumor suppressor protein p53 also interacts with Bcl-2 family proteins in a manner similar to the mode of binding between the BH3 peptides and the anti-apoptotic Bcl-2 family, and showed that the tumor suppressor p53 and pro-apoptotic Bcl-2 family members share a common molecular recognition mode with the anti-apoptotic Bcl-2 family. Thus, versatile function of Bcl-2 family proteins certainly corroborate that they are involved in several cellular network pathways and their biological roles are delicately orchestrated in response to different stimuli perturbing cellular homeostasis. Today’s drug discovery approaches are increasingly multidimensional and multidisciplinary. Genetics, systems and structural biology approaches to understand the functions, structures and mechanisms of the pro-survival Bcl-2 family members en route to cancer drug discovery program will be discussed during the talk.

Plenary Talk 2 : Internet of Everything: Revitalizing Society and Business
Scott Brown (Vice President, Enterprise Segment Asia Pacific and Japan)
Biography    

Scott Brown leads the Enterprise Segment for Cisco in Asia Pacific and Japan (APJ). This includes responsibility for Cisco’s relationship with its largest Global, Enterprise and Public Sector customers in the region. His organization includes sales, engineering and consulting resources that are experts in Architectures, Verticals and Solutions. His team also leads the entry into new market areas like the Internet of Everything, SaaS, Cloud Networking (Meraki), InterCloud and Software Defined Networking (SDN). Scott has more than 25 years of business experiencein the ICT industry. Scott held several key leadership roles in Cisco, most recently as Vice President of the Technology Solutions and Architectures organization for Asia Pacific, Japan and Greater China (APJC) where he was responsible for driving architecture product and solution sales across all customer segments and technology areas. Prior to that, Scott led the APJC Partner Business Group with responsibilities for managing relationships with the company’s 16,000+ channel partners that drove 93% of revenues across the region.

Before relocating to the region, Scott was Vice President of Worldwide Distribution Sales, where he was responsible for leading and growing Cisco’s distribution business from $9.6 billion to $13.8 billion in three years. Prior to this, Scott led Cisco’s 1,300 person Worldwide Sales Enablement organisation as Vice President for six years delivering award winning customer-facing experiences and leading development of the Cisco sales force. Scott also spent eight years in other senior field sales roles leading teams across Enterprise, Commercial and Public Sector, with management responsibility for sales, systems engineering, consulting, administrative, and regional management staff as well as managing partner relationships and marketing activities. Before joining Cisco, Scott held a number of sales management positions in the Enterprise Resource Planning (ERP) software marketplace and has an extensive knowledge of application software. Scott has taught in several MBA programs at highly-regarded American universities including the University of Wisconsin–Madison, Kellogg Graduate School of Management at Northwestern University, and The Fuqua School of Business at Duke University. Scott holds a bachelor’s degree in marketing from the University of Wisconsin-Eau Claire and a master of business administration degree from Loyola University-Chicago. Scott, his wife Sara and their four children reside in Singapore.
Abstract    

With the Internet permeating into every aspect of our life, we have huge opportunity to revitalize countries, cities and companies.   And address the challenges we are facing globally.    Scott Brown, Cisco Vice President in Asia Pacific and Japan, will show you where the future is going and how there will be a demand for talent like yours.  Come and learn how to best pursue your career and research in ICT. 

Important Dates
Submission deadline
    September 28, 2014
November 10, 2014
Notification of acceptance
    November 5, 2014
November 27, 2014
Final paper submission
    November 30, 2014
December 12, 2014
 

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